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Gemcitabine Degradation in Whole Blood from Humans, Dogs, Cats, and Horses | OMICS International | Abstract
ISSN: 2157-7579

Journal of Veterinary Science & Technology
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Research Article

Gemcitabine Degradation in Whole Blood from Humans, Dogs, Cats, and Horses

Danielle R. O’Brien1, Teri A Guerrero1, Sara Allstadt Frazier2, Robert B Rebhun3, Katherine A Skorupski3and Carlos O Rodriguez Jr3*

1Veterinary Medical Teaching Hospital, University of California-Davis, Davis, USA

2Department of Small Animal Clinical Sciences, University of Tennessee, Knoxville, USA

3Department of Veterinary Surgical and Radiological Sciences, University of California-Davis, Davis, USA

*Corresponding Author:
Carlos O Rodriguez Jr
Department of Veterinary Surgical and Radiological Sciences
University of California-Davis, Davis, USA
Tel: 530-754-2273
Fax: 530-754-2268
E-mail: [email protected]

Received date: July 09, 2012; Accepted date: August 23, 2012; Published date: August 25, 2012

Citation: O’Brien DR, Guerrero TA, Frazier SA, Rebhun RB, Skorupski KA, et al. (2012) Gemcitabine Degradation in Whole Blood from Humans, Dogs, Cats, and Horses. J Vet Sci Technol 3:119. doi:10.4172/2157-7579.1000119

Copyright: © 2012 O’Brien DR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The purpose of this in vitro study was to compare the degradation of gemcitabine (2’, 2’-difluorodeoxycytidine, dFdC), in Fresh Whole Blood (FWB) from humans, dogs, cats, and horses. A better understanding of the comparative degradation of gemcitabine may aid in the optimal design of therapeutic regimens in veterinary species. Fresh whole blood from humans, dogs, cats, and horses was spiked with dFdC and plasma was analyzed for dFdC and 2’, 2’-difluorodeoxyuridine (dFdU) by high performance liquid chromatography. In these species, there was an initial rapid degradation of dFdC with a concomitant proportional increase in dFdU. Degradation of gemcitabine appeared similar in humans, dogs, and horses (p>0.05) whereas metabolism was slower in the cat than human (p=0.014), dog (p=0.010), or horse (p=0.0015). Based on these in vitro findings, dosing schemes for humans, dogs, and horses may be similar. In contrast, gemcitabine degradation occurred more slowly in the cat; this difference may dictate a different dosing scheme for optimal response in this species.

Keywords

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