alexa Gender and Inflammatory Bowel Disease
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
Open Access

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Review Article

Gender and Inflammatory Bowel Disease

Zuzana Zelinkova1,2* and C Jannekevan der Woude2
15th Department of Internal Medicine, Gastroenterology Unit, University Hospital, Bratislava, Slovakia
2Department of Gastroenterology & Hepatology, Erasmus MC, Rotterdam, The Netherlands
Corresponding Author : Zuzana Zelinkova, MD, PhD
5th Department of Internal Medicine
Ruzinovska 6, 811 06 Bratislava, Slovakia
Tel: +421-2-48234906
Fax: +421-2-48234110
E-mail: [email protected]
Received May 10, 2014; Accepted August 06, 2014; Published August 13, 2014
Citation: Zelinkova Z, der Woude CJ (2014) Gender and Inflammatory Bowel Disease. J Clin Cell Immunol 5:245. doi: 10.4172/2155-9899.1000245
Copyright: © 2014 Zelinkova Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Men and women differ in susceptibility and exposure to environmental risk factors for inflammatory bowel disease (IBD) but various endogenous sex-determined differences in immune reactions might play a role in IBD pathogenesis as well. There is a sex-specific pattern of extra-intestinal manifestation and men and women suffer from different long-term complications of the disease. This review focuses on the gender and sex dimorphic disease profile and outlines the potential mechanisms of sex-specific pathogenesis in the view of current understanding of sex-specific immunity.


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