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Gender Differences in Patients with Intravenous Thrombolytic | 45605

Journal of Neurology & Neurophysiology

ISSN - 2155-9562

Abstract

Gender Differences in Patients with Intravenous Thrombolytic and Conservative Treatment for Acute Ischemic Stroke

Erasmia Broussalis, Alexander B. Kunz, Gernot Luthringshausen, Gunther Ladurner, Eugen Trinka and Monika Killer

Background: Stroke is the third leading cause of death and the main cause of long term disability in western societies.

Methods: In the 5 years 2005 to 2009, 2872 ischemic stroke patients were admitted to our stroke unit and registered in a national database. The data was analyzed retrospectively.

Results: 50.8% of the patients were women. The mean age of the patients was 69.5 [18 – 97]. The mean NIHS at admission was 7.2 [0 - 40], at discharge 4.9 [0 - 37]. 22.9 % of all admitted stroke patients were treated with IV thrombolysis. Women treated with thrombolysis were significantly older than men (mean age 73.7, range 28 – 97 vs. 68.2 ranges 18 – 89, p< 0.001). Although a highly significant improvement of NIHS was seen in both genders after thrombolytic treatment, women had trends towards less gain in thrombolysis

Conclusions: In a clinic with high turnover rates and a thrombolysis rate of 22.9% we could confirm that patients of both genders benefit from thrombolytic treatment, whereby women did not show such a significant improvement most likely due to older age compared to men.

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