alexa Gene Silencing – Targeting at Gene Methylation and Demethylation Patterns for the Arrest of Cancer Progression | OMICS International | Abstract
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Review Article

Gene Silencing – Targeting at Gene Methylation and Demethylation Patterns for the Arrest of Cancer Progression

Rekha Govindan1*, Sourabh Suran2 and Sanjeeva Metikala3

1 Department of Biotechnology, Aarupadai Veedu Institute of Technology, Vinayaka Missions University, India

2 CSIR—Centre for Cellular and Molecular Biology, Uppal Road, Hyderabad 500007, Andhra Pradesh, India

3 Institute for Physiological Chemistry, Martin Luther University, Halle-Wittenberg, Germany

*Corresponding Author:
Rekha Govindan
Associate Professor, Department of Biotechnology
Aarupadai Veedu Institute of Technology
Vinayaka Missions University
Rajiv Gandhi Salai, Paiyanoor
Kanchipuram, Tamil Nadu – 503604, India
Tel: 09566150994
E-mail: [email protected]

Received Date: March 17, 2014; Accepted Date: April 25, 2014; Published Date: April 28, 2014

Citation: Govindan R, Suran S, Metikala S (2014) Gene Silencing – Targeting at Gene Methylation and Demethylation Patterns for the Arrest of Cancer Progression. J Cancer Sci Ther 6:174-176. doi: 10.4172/1948-5956.1000268

Copyright: © 2014 Govindan R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The sudden occurrence or silent recurrence of tumor has been found to result from long term molecular changes at DNA level, that eventually lead to the abnormal expansion of cancer cells. One such molecular change is accounted by a distinct promoter DNA hyper-methylation pattern in certain tumor suppressing genes that are usually the check points for the regulation of gene expression in normal and progenitor cells. The hyper methylated promoter regions may account for the transcriptional inactiveness of the tumor suppressor genes. This possibility, coupled with the reversible nature of epigenetics such as demethylation has enormous significance for the prevention and control of cancer. In such circumstances, the use of demethylating drugs may re-express those genes that were silenced by aberrant DNA methylation. Understanding these epigenetic changes may help in developing specific markers to identify the molecular pathways of tumorigenesis and for deriving sensitive molecular detection strategies for a variety of tumor type.

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