Gene Silencing with Herbal Compounds against Bacteria
Moradi Fateme, Esmaeili Davoud*, Hossein Saghi and Parya Baban Zadeh
Department of Microbiology, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
- *Corresponding Author:
- Esmaeili Davoud
Department of Microbiology
Faculty of Medicine
Baqiyatallah University of Medical Sciences
Tel: 98 21 805 2941
E-mail: [email protected]
Received June 04, 2015; Accepted July 06, 2015; Published July 09, 2015
Citation: Fateme M, Davoud E, Saghi H, Zadeh PB (2015) Gene Silencing with Herbal Compounds against Bacteria. J Med Microb Diagn 4:196. doi: 10.4172/21610703.1000196
Copyright: © 2015 Fateme M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Quorum sensing (QS) is an important process involved in bacterial survival and infections, recent research has focused on the development of therapeutic agents which prevent or manage bacterial pathogenesis by inhibiting bacterial QS. Inhibition of quorum sensing offers an alternative to antibiotic mediated bactericidal or bacteriostatic approach and reduces the risk for development of resistance. Inhibition of bacterial quorum sensing by attenuating the signals can prevent the development of bacterial and fungal virulence and successful establishment of infections. Understanding the quorum sensing inhibition activity of natural bioactive phytochemicals can lead to the discovery of novel compounds and development of more effective strategies in preventing and managing microbial infections. In this study the effect of Satureja khuzestanica extract, an endemic plant of Iran, on the expression level of QS gene in P. aeruginosa and A. baumanii were investigated.