alexa Gene Therapy of Parkinson’s Disease
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Review Article

Gene Therapy of Parkinson’s Disease

Malik A*

Department of Genetics, Government College University, Near Nasir Bagh, Katchery Road, Lahore 54000, Pakistan

*Corresponding Author:
Dr. Ayesha Malik
Department of Genetics
Government College University
Near Nasir Bagh, Katchery Road
Lahore 54000, Lahore, Pakistan
Tel: 9242111000010
E-mail: [email protected]

Received date: November 23, 2016; Accepted date: February 23, 2017; Published date: February 27, 2017

Citation: Malik A (2017) Gene Therapy of Parkinson’s Disease. J Mol Genet Med 11:251 doi:10.4172/1747-862.1000251

Copyright: © 2017 Malik A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



Parkinson’s is second most common neurological disorder in the world having both sporadic and familial cases. Present Parkinson’s disease genetics taxonomy specifies 18 chromosomal regions that are also called chromosomal locus which are termed PARK. Gene therapy i.e., Use of genes as medicine, is effective and newly discovered treatment of many Central nervous system disorders including Parkinson’s disease. Direct injection was also performed but it does not give suitable results. So, scientist feel need of using different vectors for efficient delivery of genes in Central nervous system. Hence gene therapy of Parkinson’s disease involves use of both viral and non-viral vectors but viral vectors shows efficient results. Frequently used vectors for therapy of Parkinson’s disease are Lentivirus and adeno associated virus. Using these vectors many successful experiments are performed on different animals. Parkin, Glial cell-derived neurotrophic factor (GDNF) and alpha synuclein are some of the successful products for therapy of Parkinson’s disease.


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