alexa Genealogy of the Genome Components in the Highly Homogeneous Pandemic Vibrio parahaemolyticus Population | OMICS International | Abstract
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Journal of Phylogenetics & Evolutionary Biology
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Research Article

Genealogy of the Genome Components in the Highly Homogeneous Pandemic Vibrio parahaemolyticus Population

David E Loyola1, Cristian Yañez1, Nicolas Plaza1, Katherine García2 and Romilio T Espejo1,3*
1Centro Nacional de Genómica y Bioinformática, Universidad de Chile, Santiago, Chile
2Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile
3Instituto de Nutrición y Tecnología de los Alimentos, Universidad de Chile, Santiago, Chile
*Corresponding Author : Romilio T Espejo
Centro Nacional de Genómica y Bioinformática
Instituto de Nutrición y Tecnología de los Alimentos
Universidad de Chile, Santiago, Chile
Tel: +56-2978-1411
E-mail: [email protected]
Received March 15, 2016; Accepted April 18, 2016; Published April 26, 2016
Citation:Loyola DE, Yañez C, Plaza N, García K, Espejo RT (2016) Genealogy of the Genome Components in the Highly Homogeneous Pandemic Vibrio parahaemolyticus Population. J Phylogen Evolution Biol 4:165. doi:10.4172/2329-9002.1000165
Copyright: © 2016 Loyola DE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Bacterial genomes evolve through two different mechanisms: 1) changes in or occasional loss of ancestral genes, which preserve the founder clonal genealogy or frame, and 2) sporadic gains of new genes via horizontal gene transfer, which introduces DNA with a different genealogy or clonal frame. Evolution has led to the emergence of a pathogenic strain pandemic of Vibrio parahaemolyticus, which has propagated globally, causing large outbreaks of seafood-associated diarrhea. The low sequence diversity of the pathogenic strain of Vibrio parahaemolyticus genome provides a model that can reveal evolutionary mechanisms that are hidden in bacteria with a greater diversity. Here, we assess the clonal genealogy of the genome components of Vibrio parahaemolyticus and identify recombinant segments in 31 isolates obtained worldwide. By comparing whole genomes using a procedure that accounts for at least 98% of the reads obtained from any isolate after high throughput sequencing, we determined that the fraction of the whole genome retaining the founder clonal frame varied from 96.7%-100% of the accountable reads. The fraction in chromosomes with other genealogies varied from 0%-3.3% and in extra-chromosomal elements from 0%-4.2%, with the relative impact of mutation and recombination varying greatly between isolates. The likely causes for this variation are proposed.

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