General Concepts of Neurodegeneration as Specificity of Mitochondrial Pathobiology of NeuronsLawrence M Agius*
Department of Pathology, Mater dei hospital, Tal-qroqq, University of Malta medical school, MSIDA, Malta, Europe
- *Corresponding Author:
- Lawrence M Agius
Department of pathology, Mater dei Hospital
Tal-qroqq, University of Malta Medical School
MSIDA, Malta, Europe
E-mail: [email protected]
Received date: January 02, 2016 Accepted date: February 03, 2016 Published date: February 10, 2016
Citation: Agius LM (2016) General Concepts of Neurodegeneration as Specificity of Mitochondrial Pathobiology of Neurons. J Neurol Neurophysiol 7:354. doi:10.4172/2155-9562.1000354
Copyright: © 2016 Agius LM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Dimensions of inclusion within the overall concept of neurodegeneration would appear to arise as inherent consequences of the high metabolic rates of neuronal patho-physiology that dimensionally characterizes the sub-set neuronal populations.
It is valid to consider the essential neurodegenerative state as a highly inclusive pathobiologic state of response to neuronal injury that elicits multiple pathways of apoptosis. It is within the spectral manifestations for further heightened susceptibility that disorders such as Alzheimer’s, Parkinson’s, Huntington’s and also other disorders of the CNS would include also specific manifestations within the further contrasting specificities of disease states such as amyotrophic lateral sclerosis.
Hence, it is beyond specificity issues that the neurodegenerative state projects the overall dimensions of a generic cell injury within the strict confines of highly selective sub-type neuronal pathobiology in terms of the essential progressive manifestations of cell loss.