Generalized Pustular Psoriasis Associated with Ulcerative Colitis
Ayako Shimizu*, Noriaki Kamada and Hiroyuki Matsue
Department of Dermatology, Chiba University, Graduate School of Medicine, Chiba, Japan
- *Corresponding Author:
- Ayako Shimizu
Department of Dermatology, Chiba University
Graduate School of Medicine 1-8-1 Inohana
Chuo-ku, Chiba, Japan 260- 8670
Email: [email protected]
Received date: October 21, 2013; Accepted date: November 09, 2013; Published date: November 16, 2013
Citation: Shimizu A, Kamada N, Matsue H (2013) Generalized Pustular Psoriasis Associated with Ulcerative Colitis. J Clin Exp Dermatol Res 4:192. doi: 10.4172/2155-9554.1000192
Copyright: © 2013 Shimizu A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A 38-year-old Japanese woman with steroid-dependent ulcerative colitis developed generalized pustular psoriasis. Cyclosporine improved both her cutaneous lesion and bowel condition. Recent studies show that Th17 T cells are critically involved in the pathogenesis of both generalized pustular psoriasis and inflammatory bowel disease. Although molecular mechanisms seem similar, our case is the first report showing generalized pustular psoriasis associated with inflammatory bowel disease. We believe that our case may contribute to further understanding of both diseases and give us a chance to design a suitable therapy in the case of generalized Pustular psoriasis complicating inflammatory bowel disease.