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ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Review Article

Generating Aptamers for Cancer Diagnosis and Therapy

Marolt U1, Cencic A1*, Gorenjak M2 and Potrc S1

1Department of Abdominal and General Surgery, UKC Maribor, Ljubljanska 5, 2000 Maribor, Eu-slovenia

2Department of Biochemistry and Nutrition, Faculty of Medicine, University of Maribor, Eu-slovenia

*Corresponding Author:
Avrelija Cencic
Faculty of Medicine
Department of Biochemistry and Nutrition
University of Maribor, Eu-slovenia
Tel: 0038623305871
E-mail: [email protected]

Received date: May 21, 2012; Accepted date: June 21, 2012; Published date: June 22, 2012

Citation: Marolt U, Cencic A, Gorenjak M, Potrc S (2012) Generating Aptamers for Cancer Diagnosis and Therapy. Clin Exp Pharmacol 2:111.doi: 10.4172/2161-1459.1000111

Copyright: © 2012 Marolt U. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Aptamers are single-stranded dna or rna oligonucleotides or peptides that are capable of binding to specific target proteins. Aptamers are generated in a process named selex or cell-selex. They resemble antigens in respect of their highly specific binding in the lower nanomolar and/or picomolar range. In contrast to antibodies, they can be generated in vitro, are more stable molecules and have less immunogenicity, better tissue penetration and faster clearance. Aptamers can be applied in many conditions, one of them being cancer medicine, because of their ability to detect cell-specific markers within complex systems that have no specified target molecules. Moreover, aptamers can be used as therapeutic agents, which are indirectly or directly conjugated with drugs, due to their toxic, inhibitory or activating effect on target cells

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