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ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
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Review Article

Generation of Functional Hepatic Cells from Pluripotent Stem Cells

Songyan Han#, Alice Bourdon#, Wissam Hamou, Noelle Dziedzic, Orit Goldman and Valerie Gouon-Evans*

Department of Developmental and Regenerative Biology, Black Family Stem Cell Institute, Mount Sinai School of Medicine, New York, New York, USA

#Authors contributed equally

Corresponding Author:
Valerie Gouon-Evans
Department of Developmental and Regenerative Biology
Black Family Stem Cell Institute
Mount Sinai School of Medicine, New York, New York, USA
Tel: 212-241-4033
Fax: 646-537-9695
E-mail: [email protected]

Received Date: July 06, 2012; Accepted Date: August 13, 2012; Published Date: August 15, 2012

Citation: Han S, Bourdon A, Hamou W, Dziedzic N, Goldman O, et al. (2012) Generation of Functional Hepatic Cells from Pluripotent Stem Cells. J Stem Cell Res Ther S10:008. doi:10.4172/2157-7633.S10-008

Copyright: © 2012 Han S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Liver diseases affect millions of people worldwide, especially in developing countries. According to the American Liver Foundation, nearly 1 in every 10 Americans suffers from some form of liver disease. Even though, the liver has great ability to self-repair, in end-stage liver diseases including fibrosis, cirrhosis, and liver cancer induced by viral hepatitis and drugs, the liver regenerative capacity is exhausted. The only successful treatment for chronic liver failure is the whole liver transplantation. More recently, some clinical trials using hepatocyte transplantation have shown some clinical improvement for metabolic liver diseases and acute liver failure. However, the shortage of donor livers remains a life-threatening challenge in liver disease patients. To overcome the scarcity of donor livers, hepatocytes generated from embryonic stem cell or induced pluripotent stem cell differentiation cultures could provide an unlimited supply of such cells for transplantation. This review provides an updated summary of hepatic differentiation protocols published so far, with a characterization of the hepatic cells generated in vitro and their ability to regenerate damaged livers in vivo following transplantation in pre-clinical liver deficient mouse models.

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