alexa Genetic Counselling Referral Rates and Uptake of BRCA1
ISSN: 2157-7412

Journal of Genetic Syndromes & Gene Therapy
Open Access

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Research Article

Genetic Counselling Referral Rates and Uptake of BRCA1 and BRCA2 Testing among Women Diagnosed with Serous Ovarian Cancer in a Tertiary Care Cancer Centre

Bell K1,2*, Scott M3, Pond G4, Piccinin C2, Amer M2, Elit L1,2,5 and Bordeleau L1,2

1Department of Oncology, McMaster University, Hamilton, Ontario, Canada

2Juravinski Cancer Centre, Hamilton, Ontario, Canada

3Michael G. DeGroote School of Medicine, McMaster University, Hamilton, Ontario, Canada

4Ontario Clinical Oncology Group, Department of Oncology, McMaster University, Hamilton, Ontario, Canada

5Department of Gynecology/Oncology, McMaster University, Hamilton, Ontario, Canada

*Corresponding Author:
Kathleen Bell
Department of Oncology
McMaster University, Hamilton, Ontario, Canada
E-mail: [email protected]

Received date: June 15, 2013; Accepted date:July 02, 2013; Published date: July 04, 2013

Citation: Bell K, Scott M, Pond G, Piccinin C, Amer M, et al. (2013) Genetic Counselling Referral Rates and Uptake of BRCA1 and BRCA2 Testing among Women Diagnosed with Serous Ovarian Cancer in a Tertiary Care Cancer Centre. J Genet Syndr Gene Ther 4:156. doi:10.4172/2157-7412.1000156

Copyright: © 2013 Bell K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Rationale: In Ontario, all women diagnosed with serous ovarian, fallopian tube or primary peritoneal cancers are universally eligible for BRCA genetic testing (GT). We aim to document referral patterns and factors predictive of referral at the Juravinski Cancer Centre (JCC), Hamilton, ON.
Methods: Retrospective chart review of all patients with a diagnosis of serous ovarian, fallopian tube and
primary peritoneal cancers seen at the JCC from January 2009 to December 2011 was completed. The percentage of these patients referred to the JCC genetics clinic was calculated. Potential factors prognostic for referral (age and stage at diagnosis, grade, existence of biological children, family history, provider, discussion of genetics referral) were analyzed by logistic regression.
Results: 226 eligible patients were identified; 73 (32%) were referred and 61 (84%) consented to testing. 11 (18%) were found to carry a BRCA1 or BRCA2 mutation. In univariable models, stage (p=0.013), genetics discussion within the first three visits (p<0.001), and family history of breast and/or ovarian cancer (p=0.002) were significant predictors of referral. Stage (p=0.017) and early discussion (<0.001) remained significant in multivariable model.
Conclusions: The referral rate of women with serous ovarian, fallopian tube and primary peritoneal cancers to our genetics program is currently suboptimal. Stage at diagnosis and early discussion of GT were significant prognostic factors for referral. This information will be used to explore alternative delivery models of BRCA testing services to optimize uptake of GT within this eligible population, and ultimately improve care.

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