alexa Genetic Diversity and Complexity of Plasmodium Falcipar
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Genetic Diversity and Complexity of Plasmodium Falciparum Infections in Lagos, Nigeria

Muyiwa Oyebola K1,2*, Emmanuel Idowu T1, Yetunde Olukosi A2, Chimere Agomo O2, Olusola Ajibaye O2, Monday Tola2 and Adetoro Otubanjo1

1Parasitology and Bioinformatics, Faculty of Science University of Lagos, Nigeria

2Malaria Research Laboratory, Nigeria Institute of Medical Research, Lagos, Nigeria

*Corresponding Author:
Muyiwa K Oyebola
Parasitology and Bioinformatics
Faculty of Science University of Lagos, Nigeria
Tel: 234-01-7744723
E-mail: [email protected]

Received date: November 27, 2013; Accepted date: August 28, 2014; Published date: September 01, 2014

Citation: Oyebola MK, Idowu TE, Olukosi AY, Agomo CO, Ajibaye OO, et al. (2014) Genetic Diversity and Complexity of Plasmodium Falciparum Infections in Lagos, Nigeria. J Bacteriol Parasitol 5:196. doi: 10.4172/2155-9597.1000196

Copyright: © 2014 Oyebola MK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Genetic diversity in Plasmodium falciparum populations is of major importance in the outcome of antimalarial drug trialsand vaccine design. Merozoite surface protein-1 (msp 1) and msp 2 are well known antigenic markers for distinguishing persistent and new infections with P. falciparum. Methods: Parasite DNA was extracted from one hundred blood samples collected from patients confirmed by microscopy to be P. falciparum-positive followed by PCR-genotyping for msp 1 (block2) and msp 2 (block 3) allelic families. Results: All the families of msp 1 locus (K1, MAD20 and R033) and msp 2 (FC27 and 3D7) were observed. K1 was the most predominant msp 1 allelic family (60/100) followed by MAD20 (50/100) while R033 had the least frequency (45/100). In the msp 2 locus, FC27 showed higher frequency (62/100) than 3D7 (55/100). The allelic families existed alone and/or in combination with other families. However, no R033/MAD20 combination was observed. Multiplicity of Infection (MOI) with msp 1 was higher in Ikorodu (1.50) than in Lekki (1.39) while MOI with msp 2 was lower in Ikorodu (1.14) than in Lekki (1.76). There was however no significant difference in the mean MOI between the two study areas (P=0.427). Conclusion: The observation of limited parasite diversity may signal the need for the use of less subjective genotyping tools in distinguishing recrudescence and reinfections with P. falciparum during drug trials.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords