alexa Genetic Diversity of Variable Region Block 2 in the Merozoite Surface Protein-1 (MSP1) in Plasmodium falciparum Field Isolates from South-East of Iran
ISSN: 2470-6965

Malaria Control & Elimination
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Research Article

Genetic Diversity of Variable Region Block 2 in the Merozoite Surface Protein-1 (MSP1) in Plasmodium falciparum Field Isolates from South-East of Iran

Ebrahimzadeh Adel1*, and Davoodi Tahareh2

1Department of Parasitology and Mycology, Dean of Department, Associated professor, Zahedan University of Medical Sciences, Zahedan, Iran and Membership of Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

2Department of Parasitology and Mycology, MSc Student, Zahedan University of Medical Sciences, Zahedan, Iran

*Corresponding Author:
Ebrahimzadeh Adel
Department of Medical Parasitology
and Mycology, Mashahire square
Medical college, Zahedan, Iran
Tel: +98541 2417760
E-mail: [email protected]

Received Date: March 22, 2014; Accepted Date: June 25, 2014; Published Date: July 04, 2014

Citation: Adel E, Tahareh D (2014) Genetic Diversity of Variable Region Block 2 in the Merozoite Surface Protein-1 (MSP1) in Plasmodium falciparum Field Isolates from South-East of Iran. Malar Chemoth Cont Elimination 3:124. doi:10.4172/ 2090-2778.1000124

Copyright: © 2014, Adel E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Merozoite surface protein 1 of (PfMSP-1) is a leading malaria vaccine candidate. However, extensive genetic diversity of this gene in field isolates of represents a major obstacle for the development of an effective vaccine against malaria. The present study was aimed at analysing genetic polymorphisms of K1, MAD20 and RO33 allelic types of MSP-1 block 2 among isolates from Sistan and Baluchestan, Iran. In this study a total of 94 infected persons from Sistan and Baluchistan Province of Iran, were included. Blood samples were collected from March 2011 to September 2012. Block 2 of the MSP-1 gene was genotyped by allele-specific nested polymerase chain reaction (PCR) after DNA extraction. Eighty-nine (94.7%) of the 94 samples were successfully amplified; 7 distinct MSP-1 genotypes were identified by size differences on agarose gels. MAD20 was the predominant MSP-1 allelic family identified in 46.1% (41/89) of the samples while RO33 family had the least frequency (7.9%). A total of 9/89 (10.1%) samples exhibited multiple infections with two alleles at PfMSP-1. The present study shows that the level of genetic diversity is relatively low in south-east of Iran and most of infections are composed of one clone, which is consistent with an area of low malaria transmission. These data are useful for malaria prevention and control in Iran.

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