alexa Genetic Factors Contributing to Systemic Lupus Erythematosus in Tunisian Patients
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Genetic Factors Contributing to Systemic Lupus Erythematosus in Tunisian Patients

Hajer Fourati1*, Dorra Bouzid1, Olfa Abida1, Najla Kharrat3, Sameh Marzouk2, Samy Haddouk1, Constantin Fesel4, João Costa4, Mourad Ben Ayed1, Zouhair Bahloul2, Carlos Penha-Gonçalves4, Ahmed Rebai3 and Hatem Masmoudi1
1Immunology Department, Habib Bourguiba Hospital, University of Sfax, Sfax, Tunisia
2Department of Internal Medicine, Hedi Chaker, University of Sfax, Sfax, Tunisia
3Bioinformatics’ Unit, Biotechnology Center of Sfax, Sfax, Tunisia
4Instituto Gulbenkian de Ciência, Oeiras, Portugal
Corresponding Author : Hajer Fourati
Immunology Department, Habib Bourguiba Hospital
University of Sfax, 3029 Sfax, Tunisia
Tel/Fax: +216 74 45 16 60
E-mail: [email protected]
Received August 02, 2012; Accepted August 17, 2012; Published September 22, 2012
Citation: Fourati H, Bouzid D, Abida O, Kharrat N, Marzouk S, et al. (2012) Genetic Factors Contributing to Systemic Lupus Erythematosus in Tunisian Patients. J Clin Cell Immunol 3:129. doi:10.4172/2155-9899.1000129
Copyright: © 2012 Fourati H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Systematic lupus erythematosus (SLE) is a multi system autoimmune disease characterized by autoantibodies production, multi-organ damage and complex genetic inheritance. Multiple genetic and environemental factors contribute to the pathogenesis of this disease. Recent genome-wide studies, have added substantially to the number of genes associated with SLE. We performed a case control study using 138 SNPs in 93 Tunisian patients affected with lupus and 162 healthy controls. All SNPs were genotyped in a Sequenom platform. To confirm some associations, associated SNPs were analyzed using logistic regression which allows the test of association with a given SNP by adjusting for the effect of confounding variables. Association was especially reported with rs3733197 (P=0.0026, OR=2.04), rs17266594 (P=0.046, OR=1.56) in BANK1 gene, rs2070197 (P=0.0016, OR=2.31), rs2004640 (P=0.024, OR=1.54), rs10954213 (P=0.035, OR=1.53) in IRF5 gene and rs7574865 (P=0.017, OR=1.77) in STAT4 gene: previously confirmed SLE susceptibility genes. rs1800629 (P=0.00036, OR=2.26), rs4147359 (P=0.026, OR=1.55) and rs11575812 (P=0.037, OR=1.57) of TNF-α, IR2RA and IL2 genes respectively were also associated with SLE. Haplotypic analysis reported 2 susceptibility haplotypes: TGG (P=0.00421, OR=1.87) in BANK1 and TCA (P=0.00177, OR=2.34) in IRF5 genes. Our results show that numerous genes, some with known immune related function predispose to lupus.

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