alexa Genetic Markers Association in Autism Spectrum Disorder | OMICS International | Abstract
ISSN: 2472-128X

Journal of Clinical & Medical Genomics
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Review Article

Genetic Markers Association in Autism Spectrum Disorder

Nadra E Elamin1* and Laila Y AL-Ayadhi1,2
1Autism Research and Treatment Center, Shaik AL-Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Saud University, Saudi Arabia
2Department of Physiology, Faculty of Medicine, King Saud University, Riyadh, Saudi Arabia
Corresponding Author : Nadra E Elamin
Autism Research and Treatment Center
Shaik AL-Amodi Autism Research Chair
Department of Physiology, Faculty of Medicine
King Saud University, PO Box 2925, Riyadh 11461, Saudi Arabia
Tel: 00966564902960
E-mail: [email protected]
Received September 22, 2015; Accepted October 27, 2015; Published November 06, 2015
Citation: Elamin NE, AL-Ayadhi LY (2015) Genetic Markers Association in Autism Spectrum Disorder. J Clin Med Genomics 3:132. doi:10.4172/2472-128X.1000132
Copyright: © 2015 Elamin NE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Although the etiology of autism spectrum disorder (ASD) is still unclear, multiple factors have been suggested to be involved in its pathogenesis. There is a strong evidence for multiple interacting genetic factors as the main cause of autism. Hundreds of genes and genetic mutations that are involved in autism development were identified, and thus serve as useful genetic markers for identification of autism. Those genes play a key role in brain development, or may code for immune proteins. Numerous studies have suggested that autism can be inherited based on earlier twins studies which showed that monozygotic (MZ) twins had higher concordance rates than dizygotic (DZ) twins for ASDs. In this review we consider the genetic factors that underlie the pathogenesis of autism and their contribution to the disease outcome. In conclusion, candidate genes studies will highlight the role of interaction between innate immunity and neuronal activity in the etiology of autism, and it may lead to earlier diagnosis and behavioral intervention which improves ASD subjects outcomes.

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