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ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Review Article

Genetic Markers of Myocardial Infarction

Stojan Kariz1 and Daniel Petrovic2,3*
1Internal Department, General Hospital Izola, Slovenia
2Institute of Histology and Embriology, Slovenia
3Zavod Srce, Slovenia
Corresponding Author : Daniel Petrovic
Zavod Srce, Dunajska 106
1105 Ljubljana, Slovenia
Tel: +386 1543 7367
Fax: + 386 1 543 7361
E-mail: [email protected]
Received September 18, 2012; Accepted November 03, 2012; Published November 06, 2012
Citation: Kariz S, Petrovic D (2012) Genetic Markers of Myocardial Infarction. J Clin Exp Cardiolog S2:007. doi:10.4172/2155-9880.S2-007
Copyright: © 2012 Kariz S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Myocardial Infarction (MI) is a complex multifactorial disorder caused by the interaction of environmental and genetic factors. Several types of genetic studies and approaches, such as family studies, linkage analysis, candidate gene approach, and genome wide association studies, have tried to unravel the genetic background of MI. Although it is clear that the genetic component has an important role in the development of MI, in the view of many all these approaches have failed to deliver as expected. It might be due to the fact that beside genetic factors, gene-gene interactions, and epigenetic mechanisms are most probably very much involved in the setting of MI. For clinical use, a clear cut and reliable information should be available from genetic and epigenetic studies to be of help in the decision making in patients with coronary artery disease

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