Genetic Polymorphism of Adiponectin, a potential biomarker in Type-II Diabetes MellitusAsma Akhter and Mohd. Imran*
Department of Bio-Sciences, Integral University, Lucknow-226026, India
- *Corresponding Author:
- Mohd. Imran
Dept. of Biosciences, Integral University
E-mail: [email protected]
Received date: June 15, 2015; Accepted date: July 16, 2015; Published date: July 23, 2015
Citation: Akhter A, Imran M (2015) Genetic Polymorphism of Adiponectin, a potential biomarker in Type-II Diabetes Mellitus. Mol Biol 4:127. doi:10.4172/2168-9547.1000127
Copyright: © 2015 Akhter A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Adiponectin (ADIPOQ) is an abundant protein hormone which belongs to a family of adipokines. It is expressed mostly by adipocytes and is an important regulator of lipid and glucose metabolism. It was shown that decreased serum adiponectin concentration indicated insulin resistance in type 2 diabetes mellitus (T2DM) with the risk of cardiovascular complications. The fact that adiponectin is an insulin-sensitizing hormone with anti-diabetic, anti-inflammatory and anti-atherogenic properties. In this short commentary we are trying to confirm the association of ADIPOQ gene polymorphisms in subjects with T2DM. Furthermore, genetic study in a larger population will address the answer.