alexa Genetic Polymorphism of Nerve Injury-induced Protein 1 in Prostate Cancer

Journal of Prostate Cancer
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Research Article

Genetic Polymorphism of Nerve Injury-induced Protein 1 in Prostate Cancer

Jae Young Joung1, Sang Jin Lee2, Aesun Shin3, Weon Seo Park1, Jeong Eun Kim1, Ho Kyung Seo1, Jinsoo Chung1, Jung-Ah Hwang4, Seung-Hyun Hong4, Jeongseon Kim5, Kang Hyun Lee1 and Yeon-Su Lee4*

1Center for Prostate Cancer, National Cancer Center, Goyang, Korea

2Genitourinary Cancer Branch, National Cancer Center, Goyang, Korea

3Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea

4Functional Genomics Branch, National Cancer Center, Goyang, Korea

5Molecular Epidemiology Branch, National Cancer Center, Goyang, Korea

*Corresponding Author:
Yeon-Su Lee, Ph.D
Cancer Genomics Branch
National Cancer Center, Korea
Tel: +82-31-920-2550
E-mail: [email protected]

Received Date: February 17, 2016; Accepted Date: February 24, 2016; Published Date: March 02, 2016

Citation: Joung JY, Lee SJ, Shin A, Park WS, Kim JE, et al. (2016) Genetic Polymorphism of Nerve Injury-induced Protein 1 in Prostate Cancer. JPS Open Access 1:103. doi:10.4172/jps.1000103

Copyright: © 2016 Joung JY, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To investigate the association of genetic variants of nerve injury-induced protein 1 (NINJ1) with risk of prostate cancer in Korean men, we performed this association study using single nucleotide polymorphism (SNP).

Materials and methods: We enrolled 383 patients with prostate cancer and 373 healthy controls. Twentysix candidate SNPs of the NINJ1 gene were selected for genotype analysis. The distribution of each genotype and haplotype was analyzed, and their association with the incidence of prostate cancer was evaluated.

Results: None of the SNPs and haplotypes showed significant associations with prostate cancer risk in our subjects. In relation to the genotype frequency, 14 out of the 24 characterized SNPs revealed monomorphic features in cases and controls.

Conclusions: Although no association was observed between SNPs of the NINJ1 gene and prostate cancer risk, this study is meaningful because it is the first report to investigate the genetic epidemiology of the NINJ1 gene in relation to the development of prostate cancer. In addition, we observed monomorphic features of several SNPs of the NINJ1 gene in Korean men,and this finding was similar to that observed in Chinese and Japanese men based on the review of SNP database.

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