Genetic Susceptibility to Rheumatoid Arthritis in West African Patients: Correlation with Rheumatoid Factor, Anticitrullinated Protein Antibody and Radiological Damage
- *Corresponding Author:
- Zomalheto Zavier
Department of Rheumatology, National Hospital University
Hubert Maga koutoukou, Cotonou, Benin
E-mail: [email protected]
Received date: April 03, 2017; Accepted date: June 06, 2017; Published date: June 12, 2017
Citation: Zomalheto Z, Assogba M, Avohou G, Azombakin J, Laleye A (2017) Genetic Susceptibility to Rheumatoid Arthritis in West African Patients: Correlation with Rheumatoid Factor, Anticitrullinated Protein Antibody and Radiological Damage. Rheumatology (Sunnyvale) 7:221. doi:10.4172/2161-1149.1000221
Copyright: © 2017 Zomalheto Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Rheumatoïd arthritis (RA) is characterized by a multifactorial aetiology and a complex genetic background, with the major histocompatibility complex (MHC) region playing a major role.
Aim of the work: To detect the genetic susceptibility to RA in Benin population.
Patients and Methods: A prospective case-control study was conducted from December 2015 to December 2016. The selected unrelated patients suffered from RA according to the American College of Rheumatology (ACR) criteria. We genotyped HLA-DRB1*01, HLADRB1*04 and HLA-B locus between 52 west african patients with RA and 48 unrelated controls to study the susceptibility of the genes to RA among Patients. Low-resolution genotyping for HLA B and HLADRB1 alleles was performed using Polymerase Chain Reaction and Sequence-Specific Primers (PCR-SSP). The data were analysed using epidata software.
Results: Firty-two patients were recruited in the RA group and forty-eight in the control group. The mean age of the patients in the RA group was 44.6 ± 14.1 (15-69) and the sex ratio (male/female) was 0.14. The anticitrullinated protein antibody (ACPA) was present at 69.20 % of them. Among 3 genes studied, only HLADRB1*01 (OR=1.60, 95% CI=0.70–3.66) and HLADRB1*04 (OR=1.66, 95% CI=0.69–4.02) genes have shown a significant association with RA. There’s no association with RA and HLA-B genes.
Conclusion: This work has allowed us to show the involvement of HLADRB1*01 and HLADRB1*04 genes in RA and know the immunogenetic profile of some RA West African patients.