alexa Genetic Variant of the C-reactive Protein Gene and Prevalence of Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus | OMICS International | Abstract
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Genetic Variant of the C-reactive Protein Gene and Prevalence of Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus

Stavroula Papaoikonomou1*#, Dimitris Tousoulis2#, Nicholas Tentolouris1, Nikolaos Papageorgiou2, Antigoni Miliou2, Emmanuel Androulakis2, Charalambos Antoniades2 and Christodoulos Stefanadis2

1Department of Propaedeutic and Internal Medicine, Athens University Medical School, Laiko General Hospital, Greece

2Cardiology Department, Athens University Medical School, Hippokration General Hospital, Greece

#Authors contributed equally

*Corresponding Author:
Stavroula Papaoikonomou
14 Lefkosias Street, 14123
Likovrisi - Attiki, Greece
Tel: +30 210 2829405, 6932428960
E-mail: [email protected]

Received date December 24, 2014; Accepted date March 24, 2015; Published dateMarch 30, 2015

Citation: Papaoikonomou S, Tousoulis D, Tentolouris N, Papageorgiou N, Miliou A, et al. (2015) Genetic Variant of the C-reactive Protein Gene and Prevalence of Peripheral Arterial Disease in Patients with Type 2 Diabetes Mellitus. J Diabetes Metab 6:529. doi:10.4172/2155-6156.1000529

Copyright: ©2015 Papaoikonomou S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: Diabetes mellitus is strongly associated with inflammatory procedures, obesity and macrovascular complications, while genetic factors are involved in the disease pathogenesis and its complications. The aim of this study was to examine the impact of A3872G polymorphism on C-reactive protein (CRP) gene on the prevalence of peripheral arterial disease (PAD) in Greek Caucasian subjects with type 2 diabetes mellitus (T2DM).
Methods: The study population consisted of 423 patients with T2DM. The A3872G polymorphism was detected by polymerase chain reaction and appropriate restriction enzyme digestion (HpyCH4III). High sensitivity CRP was assayed by particle-enhanced immunonephelometry. PAD was diagnosed using clinical or ultrasonography criteria and/or ankle brachial index <0.9.
Results: The genotype distribution (%) in PAD patients (GG: 48.1, AG: 29.1, AA: 22.8) did not differ significantly compared to non-PAD disease subjects (GG: 53.8, AG: 26.7, AA: 19.5), (P=0.258). After adjustment for classical risk factors, carriers of “A” allele (AG+AA) compared with GG homozygotes had higher odds (OR) for PAD, (AG+AA): 82 (40.0) vs. GG: 76 (34.2), (OR 1.622, 95% confidence intervals 1.029-2.536, P=0.037).
Conclusions: In Caucasian subjects with T2DM, the GG homozygotes of the A3872G genetic polymorphism on the C-reactive protein gene may be protected from the risk of peripheral arterial disease compared to carriers of the “A” allele. These results indicate a potential genetic role of inflammation in atherosclerosis in patients with type 2 diabetes mellitus.

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]om

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7