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Journal of Neurology & Neurophysiology
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  • Review Article   
  • J Neurol Neurophysiol 2019, Vol 10(3): 488

Genetics of Epilepsy

Oluwayemi Joshua Bamikole*, Miles-Dei Benedict Olufeagba, Samuel Temitope Soge, Noah Olamide Bukoye, Taiwo Habeeb Olajide, Subulade Abigail Ademola and Olukemi Kehinde Amodu
Institute of Child Health, University of Ibadan, Nigeria
*Corresponding Author : Oluwayemi Joshua Bamikole, Institute of Child Health, University of Ibadan, Nigeria, Tel: +2347+2347068505498068505498, Email: [email protected]

Received Date: Feb 06, 2019 / Accepted Date: Mar 27, 2019 / Published Date: Aug 09, 2019

Abstract

Genetics is a branch of the human biology which provides insights about basic and vital processes which arises from birth till death, development to Apoptosis (cell death), and in disease aetiology and therapies or better methods in use of available treatments to solve human health conditions because gene functions in all biological process.

Epilepsy is a seizure that occurs without identifiable justification with a great chance of further seizures which is almost the same to the global recurrence risk of 60% after two unjustified seizures, happening over a ten years’ span. Fifty million people globally present with epilepsy ranging from about 20 to 70 cases per 100,000 in a year and Over 85% of the epilepsy cases are present in underdeveloped and even developing countries with low or middle income. Two out of three of all epilepsy occurrences are genetic, with one percent familial and ninety-nine percent sporadic. A total of about Seventy-six genes has been associated with epilepsy and the variants in these genes are usually new or inherited.

Literatures were gotten mainly from Public Medline with the use of search terms like “genetics of epilepsy”, “epilepsy”, “genetics and epilepsy”, “genetics”, epilepsy associated websites, and the NCBI.

Genetics has changed the clinical understanding of epilepsy and the reward is the provision of useful and vital information to the public at large and this has brought about interventions and breakthrough in the handling, care, treatment, diagnosis and control of epilepsy. Therefore, it is expedient that research on genetic mechanisms involved in epilepsy and the occurrence is encouraged and promoted as it will aid improvement in the knowledge of epilepsy and increase the ability to correctly diagnose the disease, and developing better treatment options.

Keywords: Genetics; Epilepsy; Seizure

Citation: Bamikole OJ, Olufeagba MDB, Soge ST, Bukoye NO, Olajide T, et al. (2019) Genetics of Epilepsy. J Neurol Neurophysiol 10:488.

Copyright: © 2019 Bamikole OJ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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