Genetics of Young Onset Colorectal CancerEsha Baichoo and Lisa A Boardman*
Department of Medicine, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
- *Corresponding Author:
- Lisa A Boardman
Mayo Clinic College of Medicine
200 First Street SW, Rochester, MN 55905, USA
E-mail: [email protected]
Received date: December 04, 2013; Accepted date: December 23, 2013; Published date: December 25, 2013
Citation: Baichoo E, Boardman LA (2013) Genetics of Young Onset Colorectal Cancer. Hereditary Genet 3:124. doi: 10.4172/2161-1041.1000124
Copyright: © 2013 Baichoo E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In the United States, more than 150, 000 cases of colorectal cancers are diagnosed annually, making colorectal cancers a major cause of morbidity and mortality. Hereditary colorectal cancers are thought to account for up to 30% of the total number, 5% of which have a known genetic background. Colorectal cancers occurring at ages less than 50 are considered young-onset and are thought to make up 2% to 8% of all cases. They are often a hallmark of a hereditary cancer predisposition. This review covers both the major and the less common hereditary syndromes associated with young-onset colorectal cancers and provide a brief overview of current genetic testing guidelines in place.