alexa Genome Editing in Mice Using CRISPR/Cas9: Achievements and Prospects
ISSN: 2168-9849

Cloning & Transgenesis
Open Access

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Review Article

Genome Editing in Mice Using CRISPR/Cas9: Achievements and Prospects

Fabien Delerue1* and Lars M Ittner1,2,3
1Transgenic Animal Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, 2052, NSW, Australia
2Dementia Research Unit, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney, 2052, NSW, Australia
3Neuroscience Research Australia, Sydney, 2036, NSW, Australia
Corresponding Author : Fabien Delerue
Transgenic Animal Unit, School of Medical Sciences
Faculty of Medicine, University of New South Wales
Sydney, 2052, NSW, Australia
Tel: 0411351446
E-mail: [email protected]
Received March 30, 2015; Accepted April 22, 2015; Published April 24, 2015
Citation: Delerue F, Ittner LM (2015) Genome Editing in Mice Using CRISPR/ Cas9: Achievements and Prospects. Clon Transgen 4:135. doi:10.4172/2168-9849.1000135
Copyright: © 2015 Delerue F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Animal models are a powerful tool to understand the mechanisms underlying physiological and pathological processes in vivo. To date, mice remain the species most commonly used for genetic manipulation. The recent development of engineered endonucleases such as Zinc Finger Nucleases (ZFN), Transcription activator-like effector nucleases (TALEN), and the Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR/Cas9) offered easy, flexible, and fast alternative to ES-Cell based gene targeting. Thanks to multiple advantages, the CRISPR system superseded its predecessors and became a popular method for genome editing. Here, we review the latest techniques to apply CRISPR editing to the mouse genome, and emphasize on the current methods used in transgenic laboratories and subsequent achievements in mice.

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