alexa Genome Mining and Comparative Genomic Analysis of Five Coagulase- Negative Staphylococci (CNS) Isolated from Human Colon and Gall Bladder | OMICS International
ISSN: 2153-0602

Journal of Data Mining in Genomics & Proteomics
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Research Article

Genome Mining and Comparative Genomic Analysis of Five Coagulase- Negative Staphylococci (CNS) Isolated from Human Colon and Gall Bladder

Ramesan Girish Nair1, Gurwinder Kaur2, Indu Khatri3, Nitin Kumar Singh2, Sudeep Kumar Maurya1, Srikrishna Subramanian3, Arunanshu Behera4, Divya Dahiya4, Javed N Agrewala1 and Shanmugam Mayilraj2*

1Immunology Laboratory, Postgraduate Institute of Medical Education and Research, Chandigarh, India

2Microbial Type Culture Collection and Gene bank (MTCC), Institute of Microbial Technology, Sector 39-A, Chandigarh -160036, India

3Protein Science and Engineering, CSIR-Institute of Microbial Technology, Sector 39-A, Chandigarh -160036, India

4Department of Surgery, Postgraduate Institute of Medical Education and Research, Chandigarh, India

*Corresponding Author:
Shanmugam Mayilraj
Microbial Type Culture Collection and Gene bank (MTCC)
Institute of Microbial Technology, Sector 39-A, Chandigarh -160036, India
Tel: +0091-172-6665
E-mail: [email protected], [email protected]

Received Date: January 28, 2016; Accepted Date: February 18, 2016; Published Date: February 28, 2016

Citation: Nair RG, Kaur G, Khatri I, Singh NK, Maurya SK, et al. (2016) Genome Mining and Comparative Genomic Analysis of Five Coagulase-Negative Staphylococci (CNS) Isolated from Human Colon and Gall Bladder. J Data Mining Genomics Proteomics 7:192. doi: 10.4172/2153-0602.1000192

Copyright: © 2016 Nair RG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Coagulase-negative Staphylococci (CNS) are known to cause distinct types of infections in humans like endocarditis and urinary tract infections (UTI). Surprisingly, there is a lack of genome analysis data in literature against CNS particularly of human origin. In light of this, we performed genome mining and comparative genomic analysis of CNS strains Staphylococcus cohnii subsp. cohnii strain GM22B2, Staphylococcus equorum subsp. strain equorum G8HB1, Staphylococcus pasteuri strain BAB3 isolated from gall bladder and Staphylococcus haemolyticus strain 1HT3, Staphylococcus warneri strain 1DB1 isolated from colon. We identified 29% of shared virulence determinants in the CNS strains which involved resistance to antibiotics and toxic compounds, bacteriocins and ribosomally synthesized peptides, adhesion, invasion, intracellular resistance, prophage regions, pathogenicity islands. 10 unique virulence factors involved in adhesion, negative transcriptional regulation, resistance to copper and cadmium, phage maturation were also present in our strains. Apart from comparing the genome homology, size and G + C content, we also showed the presence 10 different CRISPR-cas genes in the CNS strains. Further, KAAS based annotation revealed the presence of CNS genes in different pathways involved in human diseases. In conclusion, this study is a first attempt to unveil the pathogenomics of CNS isolated from two distinct body organs and highlights the importance of CNS as emerging pathogens of health care sector.

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