Genomics and Proteomics of Virulent, Avirulent and Drug Resistant Strains of Tuberculous MycobacteriaBhaskar C Harinath*, Lingaraja Jena, Gauri Wankhade and Pranita Waghmare
Bioinformatics Centre, Biochemistry and JBTDRC, MGIMS, Sevagram, Maharashtra, India
- *Corresponding Author:
- Harinath BC
JB Tropical Disease Research Centre
Mahatma Gandhi Institute of Medical Sciences
Fax: (07152) 284038
E-mail: [email protected]
Received date: June 28, 2016; Accepted date: July 25, 2016; Published date: August 01, 2016
Citation: Harinath BC, Jena N, Wankhade G, Waghmare P (2016) Genomics and Proteomics of Virulent, Avirulent and Drug Resistant Strains of Tuberculous Mycobacteria. J Pharmacogenomics Pharmacoproteomics 7:159. doi: 10.4172/2153-0645.1000159
Copyright: © 2016 Harinath BC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Mycobacterium tuberculosis (MTB), the causal organism of the oldest infectious disease tuberculosis is the leading cause of morbidity and mortality worldwide. This pathogenic organism has been evolved into variety of strains with diverse genotype, phenotype and pathogenic properties such as MTB H37Rv and CDC1551 strains which are virulent, while MTB H37Ra is an a virulent strain and MTB KZN strain is resistant to different antituberculosis drugs. Due to the advancement in genome sequencing and molecular biology, whole genomes of different MTB strains have been completely sequenced. Genomic as well as proteomic comparison among the sequenced strains will help in understanding the differences between virulent, a virulent and resistant organisms. This article reviews the information available on completely sequenced MTB strains and presents the studies reported by researchers on genomic and proteomic comparison of various MTB strains.