alexa Genotoxic Effects of Magnesium Deficiency in the Cardiovascular System and their Relationships to Cardiovascular Diseases and Atherogenesis | OMICS International | Abstract
ISSN: 2329-9517

Journal of Cardiovascular Diseases & Diagnosis
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Short Communication

Genotoxic Effects of Magnesium Deficiency in the Cardiovascular System and their Relationships to Cardiovascular Diseases and Atherogenesis

Burton M Altura1-5*, Nilank C Shah1,5, Gatha J Shah1 and Bella T Altura1,3,5

1Department of Physiology and Pharmacology, The School of Graduate Studies in Molecular and Cellular Science, State University of New York Downstate Medical Center, Brooklyn, New York, USA

2Department of Medicine, The School of Graduate Studies in Molecular and Cellular Science, State University of New York Downstate Medical Center, Brooklyn, New York, USA

3Center for Cardiovascular and Muscle Research, The School of Graduate Studies in Molecular and Cellular Science, State University of New York Downstate Medical Center, Brooklyn, New York, USA

4Bio-Defense Systems, Inc, Rockville Centre, New York, USA

5Oceana Biomedica, Estero, Florida, USA

Corresponding Author:
Altura BM
Department of Physiology and Pharmacology
State University of New Downstate Medical Center
Brooklyn, New York, USA
Tel: 718-270-2194
E-mail: [email protected]

Received May 23, 2016; Accepted May 28, 2016; Published May 31, 2016

Citation: Altura BM, Shah NC, Shah GJ, Altura BT (2016) Genotoxic Effects of Magnesium Deficiency in the Cardiovascular System and their Relationships to Cardiovascular Diseases and Atherogenesis. J Cardiovasc Dis Diagn S1:008. doi: 10.4172/2329-9517.S1-008

Copyright: © 2016 Altura BM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The authors present evidence for a novel, new hypothesis whereby magnesium deficiency (MgD) acts as a genotoxic agent which probably causes numerous, hertofore, unrecognized consequences, even over a short-term, on the physiological, molecular and biochemical machinery of cardiovascular tissues and cells. The end result of these genotoxic effects of MgD probably plays important roles in the etiology and generation of diverse cardiovascular diseases, atherosclerosis, inflammation, and strokes via alterations in the epigenome of cardiovascular tissues and cells. The importance of adequate water-borne and dietary levels of Mg is emphasized.

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