alexa Giant Cell Arteritis Related to Granulocyte-Colony-Stimulating Factor Administration
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Giant Cell Arteritis Related to Granulocyte-Colony-Stimulating Factor Administration

Katharina Lisenko1*, Norbert Blank1, Patrick Wuchter1, Tim Weber2, Martin Cremer1, Mark Kriegsmann3, Anthony D Ho1 and Mathias Witzens-Harig1

1Department of Hematology, Oncology and Rheumatology, University Heidelberg, Heidelberg, Germany

2Department of Radiology, University Heidelberg, Heidelberg, Germany

3Institute of Pathology, University Hospital Heidelberg, Heidelberg, Germany

Corresponding Author:
Katharina Lisenko
Department of Hematology, Oncology and
Rheumatology, University Heidelberg, Heidelberg, Germany
Tel: +4962215637238
E-mail: [email protected]

Received March 14, 2016; Accepted May 07, 2016; Published May 13, 2016

Citation: Lisenko L, Blank N, Wuchter P, Weber T, Cremer M, et al. (2016) Giant Cell Arteritis Related to Granulocyte-Colony-Stimulating Factor Administration. J Clin Case Rep 6:788. doi:10.4172/2165-7920.1000788

Copyright: © 2016 Lisenko K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: Granulocyte-colony-stimulating factor (G-CSF) is routinely used to mobilize stem cells for peripheral blood stem cell (PBSC) collection by leukapheresis. Although generally considered safe and effective, G-CSF has been reported to cause severe side-effects in rare cases. Methods and Results: We report a case of a 65-year-old woman with diffuse large B-cell lymphoma, who received G-CSF for PBSC mobilization for ten days and developed fever of unknown origin. She was diagnosed with giant cell arteritis (GCA) related to G-CSF with aortic involvement based on typical findings obtained by contrastenhanced computed tomography and treated with high-dose prednisone. Conclusion: GCA might have to be considered as a rare but severe side effect of G-CSF administration. Imaging studies may help to identify large vessel vasculitis in cases that cannot be confirmed by tissue biopsy.


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