Giant Cell Tumor of Soft Tissues: A Case Report and Review of Literature
Amina Mokrani, Fatma Guermazi*, Yosra Yahyaoui, Lina Hmida, Raoudha Doghri, Mouna Ayadi, Meddeb Khedija, Feriel Letaief, Nesrine Chraiet, Henda Raies, Karima Mrad and Amal Mezlini
Service d'anatomopathologie, Institut Salah Azaiez Hospital, Boulevard 9 avril, 1006, Tunisia
- *Corresponding Author:
- Fatma Guermazi
Institut Salah Azaiez Hospital
Boulevard 9 avril, 1006, Tunisia
Tel: 216 23473264
Received date: May 20, 2017; Accepted date: July 19, 2017; Published date: July 22, 2017
Citation: Mokrani A, Guermazi F, Yahyaoui Y, Hmida L, Doghri R, et al. (2017) Giant Cell Tumor of Soft Tissues: A Case Report and Review of Literature. Cancer Sci Ther 9:562-565. doi: 10.4172/1948-5956.1000474
Copyright: © 2017 Mokrani A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Primary giant cell tumor (GCT) of soft tissue (GCTST) is an extremely rare slow-growing entity bearing a high similarity to conventional bone TCG (GCTB). The term, malignant tumor of giant cells of soft tissues have been reserved for histologically high-grade lesions. Although the gold standard remains surgical carcinological resection, bisphosphonates are beginning to prove their benefit in the treatment of GCTST.
Results and Discussion: A 37-year-old man came to the outpatient department of medical oncology with a painful swelling arising from his right elbow. Magnetic resonance imaging (MRI) of the right elbow was done and revealed a 19 cm × 7 cm, T1 and T2 hypointense lesion with significant postcontrast enhancement of calcified tissue nodules, distance extension report was negative. An echo-guided biopsy of the right elbow was performed. The anatomopathological examination showed a poorly delimited encapsulated tumor proliferation composed of sheets of histiocytic cells admixed with multinucleated giant cells dispersed uniformly among this tumor. Cells were embedded in a richly vascularized tissue. No significant nuclear pleomorphism or mitotic activity was appreciated. There were focal areas of osseous metaplasia. On the basis of these date, the diagnosis of giant cell tumor of low malignant potential was retained. Due to its intra-articular extension, the mass was judged unresecable. The case was discussed in a multidisciplinary consultation meeting indicating medical treatment with zoledronic acid given the unavailability of denosumab. After 8 monthly injections of zoledronic acid, a control imaging of the right elbow and forearm concluded to tumor stability.
Conclusion: GCTST is a slow-growing tumor known as soft tissue tumor. Numerous studies show the role of bisphosphonates when complete surgical excision cannot be performed. Further studies are needed to establish a standardized treatment protocol particularly in the context of inoperable large primary GCTST.