alexa Ginkgo Biloba Extract Protects Substantia Nigral Neuron
ISSN: 2329-6895

Journal of Neurological Disorders
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Ginkgo Biloba Extract Protects Substantia Nigral Neurons from Apoptosis in PD Rat Model

Cao Fei*, Luo Fang, Zhang Lei, Su Ying, Chen Li, Hu Bo and Tong E-tang
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
Corresponding Author : Cao Fei
Department of Neurology
Union Hospital, Tongji Medical College
Huazhong University of Science and Technology
Wuhan, China
E-mail: [email protected]
Received April 11, 2013; Accepted May 27, 2013; Published May 29, 2013
Citation: Fei C, Fang L, Lei Z, Ying S, Li C, et al. (2013) Ginkgo Biloba Extract Protects Substantia Nigral Neurons from Apoptosis in PD Rat Model. J Neurol Disord 1:118. doi: 10.4172/2329-6895.1000118
Copyright: © 2013 Fei C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at
DownloadPubmed DownloadScholar Google
 

Abstract

Purpose: To investigate the apoptotic mechanism during the pathological process of Parkinson disease (PD) and explore the availability of Ginkgo biloba extract (EGb) to cure PD. Methods: Followed 6-OHDA injection stereotaxically to right side of substantia nigra pars compacta(SNc), at the date of 1, 7,14 and 21, we used biochemical, immunohistochemical, TUNEL and electron microscopic techniques to evaluate the level of apoptosis (TUNEL), monitor the degree of oxidative reaction (MDA.SOD), and to observe the change of ultrastructure of substantia nigra in the experimental PD models of rats (PD group), the EGb treatment group (EGb group) and the control group. Results: Contrast to the Control group, the number of apoptotic neurons and free radical level increased in the PD group and the EGb group, but the PD group surpassed the EGb group (p<0.05).In the PD group, the ultrastructure of substantia nigra exhibited the morphological characteristics of apoptosis from 1d to 21d. Conclusions: Free radical insult contributes to the pathological process of PD in rats. EGb may ameliorate the injury of substantia nigra through expiring free radicals during the pathological process of PD in rats.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords