alexa Glanzmann's Thrombasthenia Complicating Pregnancy | OMICS International | Abstract
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Glanzmann's Thrombasthenia Complicating Pregnancy

Chandrakala Magudapathi1*Suthanthira Kannan2Deepa Giri3
1Consultant, Department of Obstetrics & Gynaecology, G. Kuppuswamy Naidu Memorial Hospital, Nethaji road, Coimbatore, India
2Consultant, Department of Haemato oncology, G. Kuppuswamy Naidu Memorial Hospital, Nethaji road, Coimbatore, India
3Registrar, Department of Obstetrics & Gynaecology, G. Kuppuswamy Naidu Memorial Hospital, Nethaji road, Coimbatore, India
Corresponding Author : Chandrakala Magudapathi
Consultant, Department of Obstetrics & Gynaecology
G. Kuppuswamy Naidu Memorial Hospital
Nethaji road, Coimbatore, India
E-mail: [email protected]
Received April 10, 2012; Accepted April 30, 2012; Published May 14, 2012
Citation: Chandrakala M, Suthanthira K, Deepa G (2012) Glanzmann’s Thrombasthenia Complicating Pregnancy. J Clin Case Rep 2:142. doi:10.4172/2165-7920.1000142
Copyright: © 2012 Chandrakala M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Glanzmann’s thrombasthenia is a rare autosomal recessive hemorrhagic disorder caused by abnormal platelet glycoprotein complex (GP IIb-IIIa) presenting with hemorrhagic symptoms. Pregnancy is not uncommon because fertility is not affected but an association is rare. Also delivery often results in haemorrhage. Newborn thrombocytopenia is occasionally severe, but is always transitory. We report a 21-year old primigravida, who underwent vaginal delivery at term with IUGR and Oligohydramnios. Glannzmann’s thrombasthenia was characterized by aggregation and this patient went undiagnosed till adolescence until evaluated for puberty menorrhagia which is uncommon. She received single donor platelet transfusion during the intrapartum period along with tranexemic acid. Platelet transfusion may result in alloimmunization and make successive transfusions less effective. We did not use Factor VII in the intrapartum period due to cost and suspected fetal effects. Postnatally she had hematuria settled on the 2nd day with conservative management. We present this case because of association of Glanzmann’s thrombasthenia with IUGR and oligoamnios the only reported case so far.

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