alexa Gla-rich Protein (GRP): A New Player In The Burden Of Vascular Calcification
ISSN: 2329-9517

Journal of Cardiovascular Diseases & Diagnosis
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Review Article

Gla-rich Protein (GRP): A New Player In The Burden Of Vascular Calcification

Carla SB Viegas and Dina C Simes*

1Centre of Marine Sciences (CCMAR), University of Algarve, Portugal

2GenoGla Diagnostics, Centre of Marine Sciences (CCMAR), University of Algarve, Faro, Portugal

 

Corresponding Author:
Simes DC
Centre of Marine Sciences (CCMAR)
University of Algarve, Campus de Gambelas, Portugal
Tel: +351 289 800100
Fax: +351 289 800069
E-mail: [email protected]

Received date: May 13, 2016; Accepted date: June 17, 2016; Published date: June 22, 2016

Citation: Viegas CSB, Simes DC (2016) Gla-rich Protein (GRP): A New Player in the Burden of Vascular Calcification. J Cardiovasc Dis Diagn 4:245. doi:10.4172/2329-9517.1000245

Copyright: © 2016 Viegas CSB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Vascular calcification is a life-threatening complication of cardiovascular disease and an independent risk factor for morbidity and mortality. It is a complex and active cellular process that includes multiple players and regulators resembling physiological bone formation. Currently, it is generally accepted that our understanding of the molecular aetiology of vascular calcification remains incomplete. Endogenous inhibitors play a critical role in preventing vascular calcification. A relation between vitamin K and vascular calcification has been widely established and recently, the vitamin K-dependent protein, Gla-rich protein (GRP), was proposed to have an important role in vascular calcification inhibition, with clinical implications.

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