alexa Global Analysis of Proteomics for Discovery of Biomarkers in Hepatocellular Carcinoma
ISSN: 2167-0889

Journal of Liver
Open Access

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Review Article

Global Analysis of Proteomics for Discovery of Biomarkers in Hepatocellular Carcinoma

Hong Li1, Jiangbei Yuan1, Fang Zhai1, Jianqiang Zhang1, Hua He2* and Xuefeng Xia1,3*

1College of Pharmacy, Chongqing University, Chongqing 401331, China

2Institute for Viral Hepatitis, Ministry of Education, Chongqing Medical University, Chongqing 400010, China

3Houston Methodist Research Institute, Houston, Texas 77030, USA

*Corresponding Authors:
Xuefeng Xia
College of Pharmacy
Chongqing University
Chongqing 401331, China
Tel: +713-441-6665
E-mail: [email protected]
Hua He
Institute for Viral Hepatitis
Key Laboratory of Molecular Biology for Infectious Diseases
Ministry of Education
Chongqing Medical University
Chongqing 400010,China
+86 13302259211
E-mail: [email protected]

Received date: September 14, 2016; Accepted date: October 20, 2016; Published date: October 27, 2016

Citation: Li H, Yuan J, Zhai F, Zhang J, He H, et al. (2016) Global Analysis of Proteomics for Discovery of Biomarkers in Hepatocellular Carcinoma. J Liver 5:202. doi:10.4172/2167-0889.1000202

Copyright: © 2016 Li H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Hepatocellular Carcinoma (HCC) is a most lethal malignancy. At first presentation, patients often already have advanced disease, and their treatment options for cure are very limited. Measurable biomarkers for early diagnosis of HCC are urgently needed to prolong the median over-all survival rate and reduce therapeutic expenditures. Proteomics is a powerful analytical technique that has been widely applied to search for cancer biomarkers, including in HCC. High-sensitivity, high-throughput, and non-invasive technologies should be capable of contributing to early diagnosis of HCC. In this review, we provide a flow scheme for proteomic study in HCC, and an overview of technical approaches for protein quantification. In addition, we present a broad summary of the HCC biomarkers proposed by studies in recent years, which have used various quantitative proteomic approaches.


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