alexa Glucose-6-Phosphate Dehydrogenase Deficiency Unmasked b
ISSN: 2161-0665

Pediatrics & Therapeutics
Open Access

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Case Report

Glucose-6-Phosphate Dehydrogenase Deficiency Unmasked by Hyperglycemia

Francesca Silvestri*, Silvia Ortuso, Daniela Dicanio and Francesco Costantino

Department of Pediatrics, Sapienza University of Rome, Italy

*Corresponding Author:
Francesca Silvestri
Department of Pediatrics
Unit of Pediatric Diabetology
Policlinico Umberto I Hospital
Sapienza University of Rome
Roma, Italy
Tel : 0039 0649979336
Fax : 0039 0649979335
E-mail: [email protected]

Received Date: April 14, 2015; Accepted Date: April 28, 2015; Published April 30, 2015

Citation: Silvestri F, Ortuso S, Dicanio D, Costantino F (2015) Glucose-6-Phosphate Dehydrogenase Deficiency Unmasked by Hyperglycemia. Pediat Therapeut 5:240. doi:10.4172/2161-0665.1000240

Copyright: © 2015 Silvestri F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an X-linked disease responsible for moderate to severe hemolytic anemia. This is the most common erythrocyte enzyme disorder, often overpassed. A 14-year-old male patient was admitted to emergency department with hyperglycemia. He was treated initially with fluid therapy, after two hours with subcutaneous ultra-rapid insulin. After five days from hospitalization he showed scleral and skin jaundice were made diagnosis of hemolytic anemia by G6PD deficiency. There was no significant family or prior medical/ drug history. Interestingly, the hemolytic features were evidenced when blood glucose levels were returning to normal values. The insulin mediated NADPH loss may have resulted in increased erythrocyte oxidant sensitivityand a loss of sulfhydryl group’s availability, causing hemolysis to manifest.


G6PD deficiency is usually linked to drug which induced oxidative stress. Association with diabetes mellitus is infrequently reported. This case wants to emphasize that the G6PD deficiency has been unmasked by hyperglycemia until now unknown without signs and symptoms.


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