alexa Glucose-Regulated Protein 78: A Novel Therapeutic Target for Amelogenin- Induced Periodontal Tissue Regeneration
ISSN: 2168-9431

Single Cell Biology
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Glucose-Regulated Protein 78: A Novel Therapeutic Target for Amelogenin- Induced Periodontal Tissue Regeneration

Takao Fukuda1,*,#, Terukazu Sanui1,*,#, Kyosuke Toyoda1, Urara Tanaka1, Kensuke Yamamichi1, Takaharu Taketomi2, and Fusanori Nishimura1

Department of Periodontology, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, Fukuoka, Japan

2Dental and Oral Medical Center, Kurume University School of Medicine, Kurume, Fukuoka, Japan

#These authors contributed equally to this article

Corresponding Author:
Takao Fukuda
D.D.S., PhD, Assistant Professor
Department of Periodontology, Division of Oral
Rehabilitation, Faculty of Dental Science, Kyushu University
3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Tel: +81-92-642-6358
Fax: +81-92-642-6360
E-mail: [email protected]
Terukazu Sanui
D.D.S., PhD, Lecturer, Department of Periodontology
Division of Oral Rehabilitation, Faculty of Dental Science
Kyushu University, 3-1-1 Maidashi, Higashi-ku
Fukuoka 812-8582, Japan
Tel: +81-92-642-6358
Fax: +81-92-642- 6360
E-mail: [email protected]

Received date: April 29, 2016; Accepted date: May 09, 2016; Published date: May 11, 2016

Citation: Fukuda T, Sanui T, Toyoda K, Tanaka U, Yamamichi K, et al. (2016) Glucose- Regulated Protein 78: A Novel Therapeutic Target for Amelogenin-Induced Periodontal Tissue Regeneration. Single Cell Biol 5:137. doi:10.4172/2168-9431.1000137

Copyright: © 2016 Fukuda T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Amelogenin, the major component of a commercial enamel matrix derivative (Straumann® Emdogain), is commonly employed in periodontology. It is mainly used in periodontal surgery to stimulate the regeneration of periodontal tissues, including the cementum, periodontal ligament, and alveolar bone. However, the precise molecular mechanisms underlying amelogenin-induced regeneration have not yet been elucidated. Thus, to gain further insight into how amelogenin induces periodontal tissue regeneration, we performed a protein interaction screen using recombinant full-length amelogenin (rM180) as bait. Coupling affinity chromatography with proteomic analysis identified glucose-regulated protein 78 (Grp78) as a new amelogenin-binding protein. We further demonstrated that the interaction between amelogenin and Grp78 not only contributes to cell proliferation in osteoblastic cells but also enhances cell migration in periodontal ligament stem/progenitor cells. Although the potentiation effects of Grp78 should be further examined in vivo, our findings indicate the significant therapeutic potential for amelogenin-induced periodontal tissue regeneration.


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