Glycemic Control and Rate of Sputum Conversion in Diabetic Patients with Pulmonary TuberculosisDenisse Martínez-Oceguera1,2 and Rafael Laniado-Laborín1-3*
- *Corresponding Author:
- Rafael Laniado-Laborín
Emiliano Zapata 1423
Zona Centro, Tijuana, Mexico
Tel: 52 (664) 686-5626
Fax: 52 (664) 686-5626
E-mail: [email protected]
Received date: December 21, 2015 Accepted date: February 10, 2016 Published date: February 17, 2016
Citation: Oceguera DM, Laborín RL (2016) Glycemic Control and Rate of Sputum Conversion in Diabetic Patients with Pulmonary Tuberculosis. Lung Dis Treat 2:104. doi:10.4172/2472-1018.1000104
Copyright: © 2016 Oceguera DM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction The negative impact of DM and glycemic control on tuberculosis outcomes has been the subject of controversy. Twenty percent of tuberculosis (TB) cases in México are also diabetic; adequate control of glycaemia in Mexican patients due to several socioeconomic factors is rarely accomplished. Our objective was to determine the impact of glycemic control on sputum conversion and to compare the time for sputum smear and culture conversion amongst TB patients with or without diabetes. Setting Referral center for drug-resistant TB and TB complications. Retrospective analysis of cases treated during a five year period. Results 88 patients were referred for treatment; 30 patients (34.1%) had DM as a comorbidity. Twenty-seven (30.6%) had TB due to a multidrug resistant (MDR) strain; of the 30 TB-DM patients, 13 had MDR-TB (43.3%). During follow-up, 27.6% of TB patients had converted their culture by day 60 vs. 26.6% of the TB + DM patients (p = 0.58). Culture conversion for TB + DM patients with HbA1c ≥ 6.5% took 74.7 ± 32.2 days vs. 90.0 ± 25.3 days in patients with TB + DM and an HbA1c < 6.5% (p = 0.26). Conclusion Time for smear and culture conversion was not significantly different in patients with TB and patients with TB + DM, including cases with inadequate glycemic control and those with MDR-TB.