Glycosylated Hemoglobin in Diabetic Foot and its Correlation with Clinical Variables in a North Indian Tertiary Care HospitalMohammad Zubair1*, Abida Malik2 and Jamal Ahmad1
- Corresponding Author:
- Mohammad Zubair
Rajiv Gandhi Centre for Diabetes and Endocrinology
Faculty of Medicine, J.N. Medical College
Aligarh Muslim University, Aligarh 202002, India
E-mail: [email protected]
Received Date: May 07, 2015; Accepted Date: May 28, 2015; Published Date: June 03, 2015
Citation: Zubair M, Malik A, Ahmad J (2015) Glycosylated Hemoglobin in Diabetic Foot and its Correlation with Clinical Variables in a North Indian Tertiary Care Hospital. J Diabetes Metab 6:571. doi:10.4172/2155-6156.1000571
Copyright: © 2015 Zubair M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HbA1c reflects glycemia over 2-3 months and is the standard measure used to monitor glycemia in diabetic patients, but studies have not shown an association of HbA1c with DFU. We hypothesized that elevated HbA1c would be most associated with extremity of DFU/DFI. To test this hypothesis we conducted a prospective study of 161 DFU individuals treated at the R G Centre for Diabetes & Endocrinology, AMU. 64.8% were males and the 37.0% had ulcer >1 month. The majority of ulcer was neuropathic (50%) and amputation was done in 28.4%. HbA1c >6.5% were significantly associated with Wagner grades, UTG, BMI, retinopathy, nephropathy, hypertension, neuropathy and smoking. A significant correlation was found between UTG (r=-0.219, p=0.005), ulcer duration >1 month (r=-0.233, p=0.002), BMI (r=0.154, p=0.05), ESR (r=-0.169, p=0.031), Neuropathy (r=-0.007, p=0.048), nephropathy (r=-0.165, p=0.036), hypertension (r=0.207, p=0.007), retinopathy (r= 0.167, p=0.037) and smoking (r=0.164, p=0.034)with HbA1c >6.5%. The diabetic patients with A1c>6.5% showed a high risk of ulcer development in their foot. A significant correlation was observed with the clinical variables (ulcer duration >1 month, BMI, ESR, Neuropathy, nephropathy, hypertension, retinopathy and smoking with A1c>6.5% which is independent of concomitant infections in DFU patients.