Glycyrrhizic Acid as the Modulator of 11ÃÂ² -hydroxysteroid dehydrogenase (Type 1 and 2) in Rats under Different Physiological Conditions in Relation to the Metabolic SyndromeHui Ping Yaw1*, So Ha Ton1 and Khalid Abdul Kadir2
- *Corresponding Author:
- Hui Ping Yaw
School of Science, Monash University Malaysia
Jalan Lagoon Selatan, Bandar Sunway
46150, Selangor Darul Ehsan, Malaysia
E-mail: [email protected]
Received date November 20, 2014; Accepted date March 20, 2015; Published date March 30, 2015
Citation: Yaw HP, Ton SH, Kadir KA (2015) Glycyrrhizic Acid as the Modulator of 11β -hydroxysteroid dehydrogenase (Type 1 and 2) in Rats under Different Physiological Conditions in Relation to the Metabolic Syndrome. J Diabetes Metab 6:522. doi:10.4172/2155-6156.1000522
Copyright: © 2015 Yaw HP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Worldwide increase in the prevalence of metabolic syndrome has raised great attention to this disorder. Despite the effectiveness of the currently available therapeutic agents, most of the drugs elicit harmful side effects. Glycyrrhizic acid (GA) found in the licorice shrub, Glycyrrhiza glabra has been shown to exert anti-hyperglycaemic and antidyslipidaemic effects on rats under different physiological conditions via various mechanisms. The main route being the non-selective inhibition of 11β-hydroxysteroid dehydrogenase, an enzyme catalyzing the inter-conversion of active and inactive glucocorticoids. Altered intracellular glucocorticoid metabolism shows a stronger correlation to the development of metabolic syndrome compared to circulating glucocorticoid. Hence, this review focus on the role of GA in modulating glucocorticoid production in different tissues via regulation of 11β- hydroxysteroid dehydrogenase (both type 1 and 2) activities under different physiological conditions.