alexa GnT V-Catalyzed N-glycan Products are not increased in Hepatomas | OMICS International
ISSN: 2153-0637

Journal of Glycomics & Lipidomics
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Research Article

GnT V-Catalyzed N-glycan Products are not increased in Hepatomas

Akihiro Deguchi1,2, Seiji Hitoshi1, Takeshi Yoshimura1, Ichiro Fujimoto1, Takeshi Ikeda1, Akihiro Ishii1, Mikito Higashi1, Tsutomu Masaki2, Shigeki Kuriyama2 and Kazuhiro Ikenaka1*
1Division of Neurobiology and Bioinformatics, National Institute for Physiological Sciences, National Institutes of Natural Sciences, 5-1 Higashiyama, Myodaiji-cho, Okazaki, Aichi 444-8787, Japan
2Department of Gastroenterology and Neurology, Kagawa University, School of Medicine, Ikenobe 1750-1, Miki-cho, Kita-gun, Kagawa 761-0973, Japan
Corresponding Author : Kazuhiro Ikenaka
Division of Neurobiology and Bioinformatics
National Institute for Physiological Sciences
National Institutes of Natural Sciences, 5-1 Higashiyama
Myodaiji-cho, Okazaki, Aichi 444-8787, Japan
Tel: +81-564-59-5245
Fax: +81-564-59-5247
E-mail: [email protected]
Received November 26, 2012; Accepted December 26, 2012; Published December 28, 2012
Citation: Deguchi A, Hitoshi S, Yoshimura T, Fujimoto I, Ikeda T, et al. (2012) GnT V-Catalyzed N-glycan Products are not increased in Hepatomas. J Glycomics Lipidomics S5:003. doi: 10.4172/2153-0637.S5-003
Copyright: © 2012 Deguchi A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Sugar chains envelop the vast majority of the cell surface and thus have been considered to play pivotal roles in cell-to-cell and cell-to-extracellular matrix interactions. Recent studies have shown that expression of N-acetylglucosaminyltransferase (GnT) V is induced in hepatomas, and high-branched N-linked sugar chains play important roles in carcinogenesis and metastasis. However, the precise structural changes have not yet been studied in detail. Here, we compared sugar chains expressed in normal mouse liver, regenerating liver, three mouse hepatoma cell lines and Hepa 1-6-related tumors obtained by inoculation of Hepa 1-6 cells into liver or subcutaneous tissue of BALB/c nu/nu mice. The products of GnT V were found to be present in similar proportions in the mouse liver and in hepatomas, while there was a big difference in the amount of GnT IV products in these organs. Normal mouse liver and regenerating mouse liver contained small amounts of sugar chains produced by the action of GnT IV, while such chains were abundant in hepatoma cell lines and in Hepa 1-6-related tumors. Analysis of N-linked sugar chains in human livers and in hepatocellular carcinoma (HCC) revealed that both GnT IV and GnT V products are present in human liver, but their total content did not change during malignant transformation. Thus there was no increase in GnT V N-glycan products in hepatoma tissues in the mouse model or in humans.
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