Going Green: The Role of the Green Tea Component EGCG in Chemoprevention
Department of Biological Sciences, St. John’s University, NY 11439, USA
- *Corresponding Author:
- Laura Schramm
St. John’s University
Department of Biological Sciences
8000 Utopia Parkway, Queens
NY 11439, USA
Received date: February 23, 2013; Accepted date: May 10, 2013; Published date: May 20, 2013
Citation: Schramm L (2013) Going Green: The Role of the Green Tea Component EGCG in Chemoprevention. J Carcinogene Mutagene 4:142. doi: 10.4172/2157-2518.1000142
Copyright: © 2013 Schramm L. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Tea is one of the most consumed beverages worldwide, and green tea is the least processed from the buds of the Camellia sinensis plant. The most abundant component of green tea is (-)-epigallocatechin-3-gallate (EGCG), which has been the focus of many cell culture, animal and clinical trials, revealing that EGCG possesses antiproliferative, antimutagenic, antioxidant, antibacterial, antiviral and chemopreventive effects. In this review we briefly summarize the mechanism of action(s) of the green tea component EGCG, highlighting recent advances in the epigenetic regulation by EGCG. Additionally, we provide an overview of mouse chemoprevention studies and EGCG chemoprevention clinical trials.