Gonadal Dysgenesis-with Special Emphasis on the Molecular Mechanisms of SRY Mutations in Disorders of Sex Development (DSD) Reulting in Female Sex Reversal in 46XY MalesKulvinder Kochar Kaur*
Dr Kulvinder Kaur Centre for Human Reproduction, Jalandhar, India
- *Corresponding Author:
- Kulvinder Kochar Kaur
Dr kulvinder Kaur Centre for Human Reproduction
Received date: December 24, 2015; Accepted date: February 18, 2016; Published date: February 22, 2016
Citation: Kaur KK (2016) Gonadal Dysgenesis-with Special Emphasis on the Molecular Mechanisms of SRY Mutations in Disorders of Sex Development (DSD) Reulting in Female Sex Reversal in 46XY Males. Hereditary Genet 5:164. doi:10.4172/2161-1041.1000164
Copyright: © 2016 Kaur KK. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
SRY related high mobility group box (Sox) transcription factors have emerged in the animal kingdom to help cells maintain stemness, commit to a specific lineage, proliferate or die. Encoded by 20 genes in humans and mice they show a highly conserved high-mobility group boxdomain, which was originally identified in SRY, the sex determining region on the Y chromosome. This has derived from a high mobility group domain characterized of chromatin associated proteins. HMG (high mobility group) non histone chromosomal proteins include the AT hook, HMGN, and HMG domain families.