alexa Gram-Positive S. mitis Become Sensitive to Colistin and Nalidixic Acid when Grown in Xylitol
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Research Article

Gram-Positive S. mitis Become Sensitive to Colistin and Nalidixic Acid when Grown in Xylitol

Gail Czarnecki2, Prabani Dissanayake1 and Sunil Palchaudhuri1*

1Department of Immunology and Microbiology, Wayne State University, School of Medicine, Detroit, MI, USA

2Department of Orthodontics and Pediatric Dentistry, University of Michigan, School of Dentistry, Ann Arbor, MI, USA

Corresponding Author:
Sunil Palchaudhuri
Department of Immunology and Microbiology
Wayne State University, School of Medicine
Detroit, MI, USA
Tel: 313-577-1313

Received Date: November 25, 2013; Accepted Date: December 10, 2013; Published Date: December 12, 2013

Citation: Czarnecki G, Dissanayake P, Palchaudhuri S (2013) Gram-Positive S. mitis Become Sensitive to Colistin and Nalidixic Acid when Grown in Xylitol J Mol Genet Med 7:92 doi:10.4172/1747-0862.1000092

Copyright: © 2013 Czarnecki G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited



The generation time of diplococcic viridans group streptococci, S. mitis is unusually prolonged when grown in rich broth containing xylitol (2% or higher concentrations). These xylitol-exposed streptococci predominantly grow in chains of varying lengths with heterogeneity of color: pink, purple and pink and purple combined. The pink portion of these bacterial chains appears to be thinner than the purple portion indicating a reduction in cell wall thickness. In support of optical microscopy, scanning electron microscopy of the same bacterial population demonstrates a considerable reduction of sizes but still in chains. In these chains, there is a variation in size indicating that all members of the diplococcic S. mitis population are not equally affected. Apparently, the partially affected viable population of S. mitis, becomes sensitive to colistin and nalidixic acid when grown in xylitol.

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