Green Synthesis of Tetrazines and their Role as Human Cytomegalovirus (HCMV) Protease InhibitorSingh P1* and Kumari K2
- *Corresponding Author:
- Prashant Singh
ARSD College, University of Delhi
New Delhi-110 021, India
E-mail: [email protected]
Received March 21, 2016; Accepted April 05, 2016; Published April 16, 2016
Citation: Singh P, Kumari K (2016) Green Synthesis of Tetrazines and their Role as Human Cytomegalovirus (HCMV) Protease Inhibitor. J Theor Comput Sci 3:145. doi:10.4172/2376-130X.1000145
Copyright: © 2016 Singh P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Herein, we report a one-pot, efficient, and environmentally benign synthesis of biological and pharmacological potent tetrazines and tetrazines were synthesized via reaction of benzyl cyanide and hydrazine in the presence of sodium nitrite and hydrochrloic acid at room temperature in bronsted acidic ionic liquid as a green solvent and efficient catalytic media. Further, computational studies of the synthesized tetrazines have been performed against Human cytomegalovirus (HCMV) protease and found to inhibitors for HCMV. Therefore, tetrazines have been proposed as potent antiviral agents.