alexa Green Tea Extract Induces Apoptosis in the AGS Gastric Carcinoma Cell Line | OMICS International
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

Green Tea Extract Induces Apoptosis in the AGS Gastric Carcinoma Cell Line

Fernando Gonzalez*
Department of Microbiology and Immunology, Arizona College of Osteopathic Medicine, Midwestern University, USA
Corresponding Author : Fernando Gonzalez
Department of Microbiology and Immunology
Arizona College of Osteopathic Medicine
Midwestern University, 19555 N. 59th Avenue
Glendale, AZ 85308, USA
Tel: 623-572-3723
Fax: 623-572-3673
E-mail: [email protected]
Received March 14, 2014; Accepted April 23, 2014; Published April 28, 2014
Citation: Gonzalez F (2014) Green Tea Extract Induces Apoptosis in the AGS Gastric Carcinoma Cell Line. Nat Prod Chem Res 2:130. doi: 10.4172/2329-6836.1000130
Copyright: © 2014 Gonzalez F. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Green tea has long been thought to possess anticancer properties. Additionally, the polyphenol components of green tea have demonstrated ability to inhibit 26S proteasome function. As there have been reports describing varied responses of gastric carcinoma cells to green tea treatment, the role of green tea treatment on proteasome function in the gastric carcinoma cell line AGS was investigated. Presented here are findings demonstrating that green tea extract is capable of inhibiting proteasome function of AGS cells. Furthermore, treatment of AGS cells with the green tea polyphenol (-)-Epigallocatechin-3-gallate resulted in a similar level of proteasome inhibition. It was also discovered in this study that proteasome inhibition in AGS cells resulted in a buildup of Kip1/p27 and IκBα, proteins that are involved in the progression through the G1/S checkpoint during cell division. Proteasome inhibition by (-)-Epigallocatechin- 3-gallate led to induction of apoptosis of AGS cells. Our results described here strongly suggest that green tea consumption is capable of inducing programmed cell death in gastric carcinoma cells through inhibition of proteasome activity. It should be noted, however, that consumption of green tea during anti-cancer protocols has been reported to reduce the effectiveness of a specific subset of chemotherapeutic compounds. In summary, consumption of green tea in gastric carcinoma patients may be effective in targeting cancer cells and slowing the progression of gastric cancers. Future studies of these natural products may provide some structural information which will allow for the development of the next generation of anti-cancer chemotherapeutics.

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