alexa Group Sequential Survival Trial Designs Against Histori
ISSN: 2155-6180

Journal of Biometrics & Biostatistics
Open Access

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Research Article

Group Sequential Survival Trial Designs Against Historical Controls under the Weibull Model

Jianrong Wu* and Xiaoping Xiong

Department of Biostatistics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA

*Corresponding Author:
Jianrong Wu
Department of Biostatistics
St. Jude Children’s Research Hospital
262 Danny Thomas Place, Memphis
TN 38105, USA
Tel: (901) 495-2850
Fax: (901) 495-4585
E-mail: [email protected]

Received date: July 04, 2014; Accepted date: August 04, 2014; Published date: August 11, 2014

Citation: Wu J, Xiong X (2014) Group Sequential Survival Trial Designs Against Historical Controls under the Weibull Model. J Biomet Biostat 5:209. doi:10.4172/2155-6180.1000209

Copyright: © 2014 Wu J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are are credited.



In this paper, two parametric sequential tests are proposed for historical control trial designs under the Weibull model. The proposed tests are asymptotically normal with properties of Brownian motion. The sample size formulas and information times are derived for both tests. A multi-stage sequential procedure based on sequential conditional probability ratio test methodology is proposed for monitoring clinical trials against historical controls.


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