Gugulipid, an Extract of Ayurveda Medicine Plant Commiphora Mukul as a Potent Agent for Cancer Chemoprevention and Cancer ChemotherapyMichelle Xiao and Dong Xiao*
Department of Urology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15232, USA
- *Corresponding Author:
- Dong Xiao, MD, Ph.D
Department of Urology
University of Pittsburgh Cancer Institute
University of Pittsburgh School of Medicine
University of Pittsburgh, Shadyside Medical Center
Suit G19, 5200 Centre Avenue, Pittsburgh, PA 15232, USA
E-mail: [email protected]
Received date: November 14, 2012; Accepted date: November 15, 2012; Published date: November 16, 2012
Citation: Xiao M, Xiao D (2012) Gugulipid, an Extract of Ayurveda Medicine Plant Commiphora Mukul as a Potent Agent for Cancer Chemoprevention and Cancer Chemotherapy. Med chem 2:e105. doi:10.4172/2161-0444.1000e105
Copyright: © 2012 Xiao M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Gugulipid (GL), an extract of Commiphora mukul, has been safely used for thousands of years in the Indian Ayurveda medicine practice for the treatment of different ailments and has been used recently in many clinical trials that focused on its cholesterol-lowering effect. GL has recently been paid great attention for its cancer chemopreventive and chemotherapeutic potential. Z- and E-Guggulsterone have been identified as the major active components of GL. Studies have shown that GL as well as Guggulsterones can inhibit cancer growth in vitro and in vivo and lead to prevention of cancer initiation, promotion and progression. Although the action mechanisms of GL are not completely understood, GL has been revealed as a multitargeted cancer chemopreventive and chemotherapeutic agent. The increased understanding of the anti-cancer activity of GL and its molecular targets would allow us to improve its efficacies in different types of human cancers by single and/or combination strategies.