alexa Guillain Barre Syndrome and Matrix Metalloproteinases
ISSN: 2329-6895

Journal of Neurological Disorders
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Review Article

Guillain Barre Syndrome and Matrix Metalloproteinases

Dash S1, Kamath U1, Pai A2 and Rao P3*
1Department of Biochemistry, Melaka Manipal Medical College, Manipal Campus, Manipal University, India
2Department of Neurology, Kasturba Medical College, Manipal, Manipal University, India
3Department of Biochemistry, Kasturba Medical College, Manipal, Manipal University, India
Corresponding Author : Dr. Pragna Rao
Department of Biochemistry
Kasturba Medical College
Manipal, Manipal University, India
Tel: 08202922532
E-mail: [email protected]
Received May 13, 2015; Accepted May 26, 2015; Published May 29, 2015
Citation: Dash S, Kamath U, Pai A, Rao P (2015) Guillain Barre Syndrome and Matrix Metalloproteinases. J Neurol Disord 3:233. doi: 10.4172/2329-6895.1000233
Copyright: © 2015 Dash S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Guillain Barre Syndrome (GBS) is an autoimmune inflammatory neuropathy. It affects all age group of both sexes and can lead to morbidity if untreated. It is usually preceded by an infection and has a fast progression. There are two treatment modalities practiced primarily, plasmapheresis and intravenous immunoglobulin therapy. Matrix metalloproteinases have been indicated to play a role in pathogenesis of GBS by mediating inflammation and disrupting blood nerve barrier. Greater focus needs to be put on these MMP’s as marker enzymes for early detection and/or diagnosis and as targets for therapy.

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