alexa Haematological Changes in Trypanosoma brucei brucei Inf
ISSN: 0974-8369

Biology and Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Haematological Changes in Trypanosoma brucei brucei Infected Wistar Rats Treated with a Flavonoid Mixture and/or Diminazene Aceturate

Kobo PI1*, Ayo JO2, Tagang Aluwong2, Zezi AU3 and Maikai VA4

1Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria

2Department of Physiology, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Nigeria

3Department of Pharmacy and Therapeutics, Faculty of Pharmaceutical Science, Ahmadu Bello University, Zaria, Nigeria

4College of Agriculture and Animal Science, Ahmadu Bello University, Mando-Kaduna, Nigeria

*Corresponding Author:
Kobo PI
Department of Pharmacology and Toxicology
Faculty of Veterinary Medicine
Ahmadu Bello University, Zaria, Nigeria
Tel: +234806549004
E-mail: [email protected]

Received Date: July 16, 2014; Accepted Date: September 29, 2014; Published Date: October 06, 2014

Citation: Kobo PI, Ayo JO,Tagang Aluwong, Zezi AU and Maikai VA (2013) Haematological Changes in Trypanosoma Brucei Brucei Infected Wistar Rats Treated with a Flavonoid Mixture and or Diminazene Aceturate. Biol Med 6:213. doi:10.4172/0974-8369.1000213

Copyright: © 2014 Kobo, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The aim of the study was to evaluate the effect of treatment with DAFLON® 500 mg (DF) and/or diminazene aceturate (DZ) on hematological parameters in rats, infected with Trypanosoma brucei brucei. Rats in the control group were administered with distilled water (DW) only (5 mL/kg), while those in other groups were infected with Trypanosoma brucei brucei (106 cells/ml), and treated with DF and/or DZ. Packed cell volume (PCV), haemoglobin (Hb) concentration, erythrocyte (RBC) and neutrophil counts were lower in the infected untreated and DF-treated group, than in any other group. Total leucocyte, lymphocyte, platelet counts and mean corpuscular volume (MCV) decreased in the infected untreated group, compared to values obtained in those administered with DF and/or DZ. The MCV reduced in the DZ-treated group, compared to the groups treated with DF and the combination of DF and DZ. Mean corpuscular haemoglobin concentration (MCHC) was lower in the infected untreated and DF treated group than in the DW or DZ group. Rats administered with DZ had higher leucocyte and lymphocyte counts compared to those in DF-treated group. It is concluded that the administration of DF and/or DZ ameliorated the anaemia caused by Trypanosoma brucei brucei - infection in Wistar rats.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version