Haemophilus influenzae and Haemophilus parainfluenza in Cystic Fibrosis: 15 Years ExperienceRosanne Ebbing2, Colin F Robertson1,2,3 and Philip J Robinson1,2,3*
- *Corresponding Author:
- P.J. Robinson
Department of Respiratory Medicine
The Royal Children’s Hospital Melbourne
E-mail: [email protected]
Received date: June 22, 2015 Accepted date: August 25, 2015 Published date: August 28, 2015
Citation: Ebbing R, Robertson CF, Robinson PJ (2015) Haemophilus influenzae and Haemophilus parainfluenza in Cystic Fibrosis: 15 Years Experience. J Medical Microbiol Diagnosis S5:004. doi:10.4172/2161-0703.S5-004
Copyright: © 2015 Ebbing R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Haemophilus influenzae and Haemophilus parainfluenzae are commonly identified in the lower airways of patients with cystic fibrosis (CF). Little is known of the change in prevalence and antimicrobial susceptibility in this population over time. We examined the epidemiology of both organisms over 15 years in our CF clinic.
Results: 1538 isolates from respiratory specimens of 349 CF patients over 15 years were investigated. Annual prevalence increased significantly for both bacteria, being more pronounced for H. parainfluenzae. Average percentage of resistant cultures increased by 46% (H. Influenzae) and 61% (H. Parainfluenzae). For H. influenzae, resistance to ampicillin was 34.4%, co-trimoxazole 21.4%. For H. parainfluenzae, resistance to ampicillin was 50.0%, co-trimoxazole 26.8%. Resistance in H. influenzae and H. parainfluenzae to ampicillin and in H. parainfluenzae to amoxicillin/ clavulanic acid and co-trimoxazole increased over the study.
Conclusion: This present study has shown an increased annual prevalence of H. influenzae and H. parainfluenzae in a large group of CF patients. Resistance to ampicillin significantly increased for H. influenzae and H. parainfluenzae, but increased resistance to amoxicillin/ clavulanic acid and co-trimoxazole was only significant in H. parainfluenzae.