Hair Regrowth Following Topical HairUpTM Treatment in Subjects with Alopecia Totalis (AT) and Alopecia Universalis (AU): A Retrospective Analysis of Efficacy and Cosmetic Acceptability
- *Corresponding Author:
- Nir Y
SPRIG Consulting LLC, Wilmette, IL, USA
8 Hadar St. Caesarea, Israel
E-mail: [email protected]
Received date: September 15, 2016; Accepted date: September 28, 2016; Published date: October 4, 2016
Citation: Jaffe A, Nir Y, Zbar AP, Gonen-Shahar M, Gonen S (2016) Hair Regrowth Following Topical HairUpTM treatment in Subjects with Alopecia Totalis (AT) and Alopecia Universalis (AU): A Retrospective Analysis of Efficacy and Cosmetic Acceptability. Hair Ther Transplant 6:1000144. doi: 10.4172/2167-0951.1000144
Copyright: © 2016 Jaffe A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Alopecia areata is a common disorder 5-30% of cases representing alopecia totalis (AT) or alopecia universalis (AU), the most severe forms of the disorder. In the absence of any FDA-approved treatments, topical Hair UpTM has shown promising results but has not been subject to formal study. The following study reports the initial use of a customized natural topical treatment-Hair UpTM in an unselected population of AT and AU patients. It includes a cohort of patients with an intention to treat and aims to serve as a pilot study to a prospective study. Methods: A retrospective analysis of AT/AU patients treated with topical Hair UpTM was conducted. The study assessed type of hair growth and the percentage hair regrowth using the severity alopecia tool (SALT) scoring system with a subjective determination of the cosmetic acceptability of response over a 2 year follow-up period. Results: Of 109 subjects, 53 with available data were eligible for analysis including 26 minors <18 years of age (mean age 10.8+4.7 years) and 27 adults (mean age 39.1+12.2 years). There were 34 subjects with AU and 19 with AT. Treatment appeared to bevery safe with minimal contact reactivity. Almost all subjects achieved vellus hair growth (96%; 51/53) with 43% (23/53) developing full abundant hair and 81% (43/53) showing a return to quality vellus hair as early as 3 months after commencement of treatment. SALT scores exceeded 75% in 75% (21/28) of cases. Overall, 94% (17/18) of minors ultimately achieved a subjective cosmetically acceptable result compared with 58% (11/19) of adults (p=0.02). Conclusion: Topical Hair UpTM treatment of subjects with Alopecia totalis (AT) and Alopecia universalis (AU) is effective and safe with a high rate of terminal hair regrowth and cosmetic acceptability, particularly in minors.